College of Scienc Research
1/3/2013

CHEMICAL STUDIES ON 3,6-DICHLOROPYRIDAZINE
Mohamed H. Sherif, Gamal A. Ahmed, Adel A. Elbahnasawy and Enian O.

Helal
Department of Chemistry, Faculty of Science, Zagazig University, Egypt
ABSTRACT
Reaction of 3.6-dichloropyridazine (1) with acid hydrazides, p-toluene
sulfonylhydrazine, anthranilic acid derivatives and ammonium hydroxide afforded the
compounds (2a,b), (3), (4a,b) and (5) respectively. Compound (5) reacted with
aromatic aldehydes yielded the Shiff s bases (6) and (7). Compound (6) Reacted with
anthranilic acid derivatives and gave (8). Also, compound (1) easily reacted with 2-
chlorobenzylamine, sodium azide and thioscmicarbazide afforded the compounds (9),
(10) and (11) respectively.
Keywords: 3,6-dichloropyridazine; acid hydrazides; p-toluene sulfonylhydrazine;
anthranilic acid derivative; ammonium hydroxide

 

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